Institute of Molecular Biology

SARS-CoV-2 VLPs Wuhan

Wild Type SARS-CoV-2 virus-like particles containing all the structural proteins.

Internalization into ACE2-NeonGreen-expressing cells
Cell: U2OS

Internalization into Dynamin-GFP-expressing cells
Cell: VeroE6

VLPs pre-incubated with anti-SARS-CoV-2 antibodies
Cell: VeroE6

Internalization in cells treated with Dynamin inhibitor (Dynole 34-2)
Cell: VeroE6

Internalization in cells, in which tubulin is labelled
Cell: VeroE6

Internalization in cells expressing Rab-5-GFP
Cell: VeroE6

Internalization in cells treated with LysoTracker
Cell: VeroE6

Internalization of VLP-Wuhan:(E, S, M&M-mCherry) into U2OS cells
Cell: U2OS

Parallel videos showing the volume of a single U2OS cell treated with SASR-CoV-2 VLP-Wuhan ( E,S, M&M-mCherry).
Cell: U2OS

Slow motion movie of the internalization into Dynamin-GFP-expressing cells
Cell: VeroE6

Internalization of VLP-Wuhan:(E, S, N, M&M-mCherry&M-pHluorin) into VeroE6.
Cell: VeroE6

Internalization of VLP-Wuhan:(E, S, N, M&M-mCherry&M-pHluorin) into A549 cells.
Cell: A549

Internalization of SARS-CoV-2-Wuhan:(E, S, N&N-eGFP, M&M-mCherry, T20 RNA) VLPs into A549 cells
Cell: A549

Splitting of a single VLP-Wuhan (N&N-EGFP, E, S, M, M-mCherry, T20 RNA)
Cell: A549

Internalization of VLP-Wuhan(E, S, N, M&M-pHluorin) into A549 cells expressing mCherry
Cell: A549

Internalization of VLP-Wuhan(E, S, N, M&M-pHluorin) into VeroE6 cells expressing mCherry
Cell: VeroE6